孔祥复院士集

第一部分 奋斗历程 1

孔祥复院士的奋斗历程 3

第二部分 学术贡献 7

一、孔祥复院士的主要学术论文 9

Purification and Properties of a Soluble Factor Required for the Deoxyribonucleic Acid-directed in Vitro Synthesis of β-Galactosidase 9

Effect of Human Recombinant Interferon on Cytotoxic Activity of Natural Killer（NK） Cells and Monocytes 19

Transformation of NIH 3T3 Cells by Microinjection of Ha-ras p21 Protein 24

Mutational Analysis of a ras Catalytic Domain 28

Insulin Induction of Xenopus laevis Oocyte Maturation Is Inhibited by Monoclonal Antibody against p21 ras Proteins 40

Microinjection of Transforming ras Protein Induces c-fos Expression 45

Ascorbic Acid Inhibits ROS Production, NF-kB Activation and Prevents Ethanol-induced Growth Retardation and Microencephaly 51

Identification and Preliminary Characterization of Proteincysteine Farnesyltransferase 60

Inhibition of Serum-and Ras-Stimulated DNA Synthesis by Antibodies to Phospholipase C 67

Cytogenetics of Papillary Renal Cell Tumors 73

Regulation of Intracellular Actin Polymerization by Prenylated Cellular Proteins 81

Ras Mediates Translation Initiation Factor 4E-induced Malignant Transformation 93

Nerve Growth Factor Stimulation of the Ras-Guanine Nucleotide Exchange Factor and GAP Activities 108

Universal Cellular Tropism？ 114

A Truncated Bone Morphogenetic Protein 4 Receptor Alters the Fate of Ventral Mesoderm to Dorsal Mesoderm: Roles of Animal Pole Tissue in the Development of Ventral Mesoderm 115

Suppression of in vivo Tumor Growth and Induction of Suspension Cell Death by Tissue Inhibitor of Metalloproteinases （TEMP）-3 122

The Role of BMP-4 and GATA-2 in the Induction and Differentiation of Hematopoietic Mesoderm in Xenopus Laevis 132

TIMP-3 Induces Cell Death By Stabilizing TNF-α Receptors On The Surface of Human Colon Carcinoma Cells 143

Malignant Transformation of Mammalian Cells Initiated by Constitutive Expression of the Polo-like Kinase 156

Lysozyme and RNases as Anti-HIV Components in β-core Preparations of Human Chorionic Gonadotropin 167

Mouse Peroxiredoxin V Is a Thioredoxin Peroxidase That Inhibits p53-Induced Apoptosis 173

Functional p53 is Required for Triptolide-induced Apoptosis and AP-1 and Nuclear Factor-kB Activation in Gastric Cancer Cells 181

Gene Therapy for New Bone Formation Using Adenoassociated Viral Bone Morphogenetic Protein-2 Vectors 192

Inhibition of SARS-Associated Coronavirus Infection and Replication by RNA Interference 202

Suppression of RelA/p65 Nuclear Translocation Independent of IkB-α Degradation by Cyclooxygenase-2 Inhibitor in Gastric Cancer 205

Phosphatidylinositol 3-Kinase Signaling Is Involved in Neurogenesis during Xenopus Embryonic Development 215

A Critical Role of Pax6 in Alcohol-induced Fetal Microcephaly 223

Cyclooxygenase-2 Inhibitor （SC-236） Suppresses Activator Protein-1 Through c-Jun NH2-Terminal Kinase 231

Proteomic Profiling Between CNE-2 and Its Strongly Metastatic Subclone S-18 and Functional Characterization of HSP27 in Metastasis of Nasopharyngeal Carcinoma 244

The Adamantane-Derived Bananins Are Potent Inhibitors of the Helicase Activities and Replication of SARS Coronavirus 254

Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant 266

HSF1 Down-regulates XAF1 through Transcriptional Regulation 281

Correlation Between the Single-Site CpG Methylation and Expression Silencing of the XAF1 Gene in Human Gastric and Colon Cancers 293

Molecular Cloning of a Human Monocyte-Derived neutrophil Chemotactic Factor （MDNCF） and the Induction of MDNCF mRNA by Interleukin 1 and Tumor Necrosis Factor 303

Lentivirus-Mediated RNA Interference Targeting Enhancer of Zeste Homolog 2 Inhibits Hepatocellular Carcinoma Growth Through Down-Regulation of Stathmin 311

Cell Cycle-Related Kinase: A Novel Candidate Oncogene in Human Glioblastoma 322

Suppression of FHL2 Expression Induces Cell Differentiation and Inhibits Gastric and Colon Carcinogenesis 338

Comparative Proteomic Analysis of Mesenchymal Stem Cells Derived from Human Bone Marrow, Umbilical Cord, and Placenta: Implication in the Migration 351

Proteomic Identification of Molecular Targets of Gambogic Acid:Role of Stathmin in Hepatocellular Carcinoma 363

MicroRNA-15b Regulates Cell Cycle Progression by Targeting Cyclins in Glioma Cells 374

The Gene Transfection Efficiency of a Folate-PEI 600-cyclodextrin Nanopolymer 382

RNAi Targeting EZH2 Inhibits Tumor Growth and Liver Metastasis of Pancreatic Cancer in vivo 396

miR-200a Regulates Epithelial-Mesenchymal to Stem-like Transition via ZEB2 and β-Catenin Signaling 405

EZH2 Protein: a Promising Immunomarker for the Detection of Hepatocellular Carcinomas in Liver Needle Biopsies 417

Effective Melanoma Immunotherapy with Interleukin-2 Delivered by a Novel Polymeric Nanoparticle 429

Primate-Specific microRNA-637 Inhibits Tumorigenesis in Hepatocellular Carcinoma by Disrupting Signal Transducer and Activator of Transcription 3 Signaling 441

EZH2 Supports Nasopharyngeal Carcinoma Cell Aggressiveness by Forming a Co-repressor Complex with HDAC1/HDAC2 and Snail to Inhibit E-cadherin 453

Functional Characterization of a PEI-CyD-FA-Coated Adenovirus as Delivery Vector for Gene Therapy 466

二、孔祥复院士学术年表 476

孔祥复院士论文目录 476

孔祥复院士专利目录 515

孔祥复院士著作目录 516

孔祥复院士主要奖项目录 518

第三部分 治学之道 519

我所认识的孔院士 521

印象中的孔院士 522

我认识的孔祥复院士 523

“烈士暮年，壮心不已”——我所知道的孔祥复院士 524

生物医药的先驱科研学者的楷模 526

孔院士兢兢业业、乐于助人 527

虚怀若谷，大家风范 528

第四部分 大师风范 529

师恩难忘 531

随和而坚毅的学者——记我的导师孔祥复院士 533

伟大而平凡的孔祥复院士 534

身正为师，学高为范 536

我的人生灯塔——孔祥复院士 537

引领我走进科学殿堂的科学家——孔祥复院士 539

第五部分 社会影响 541

孔祥复：回家 543

高新技术应用医学范畴为病患诊治带来新曙光 547

第六部分人生风采 549