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INTRODUCTION 3
Production of Experimental Renal Hypertension by Various Methods 6
Unilateral and bilateral nephrectomy 6
Reduction of the amount of functioning renal tissue 6
The effect of a nephrotic substance 7
Irradiation with roentgen rays 7
Occlusion of one or both ureters 7
Compression of the kidneys 8
Embolism 8
Passive hyperemia 8
Permanent occlusion of the main renal artery，vein，and ureter 8
Arteriovenous anastomosis 9
Occlusion of the main renal arteries 9
Ligation of branches of the main renal artery 9
Constriction of the main renal artery 9
The administration of sterols 9
PRODUCTION OF EXPERIMENTAL RENAL HYPERTENSION BY CONSTRICTION OF MAIN RENAL ARTERY 12
EFFECT ON BLOOD PRESSURE OF MODERATE CONSTRICTION OF THE MAIN ARTERY OF ONLY ONE KIDNEY 15
EFFECT ON BLOOD PRESSURE OF MODERATE CONSTRICTION OF BOTH MAIN RENAL ARTERIES：THE BENIGN PHASE OF EXPERIMENTAL RENAL HYPERTENSION 18
EFFECT ON BLOOD PRESSURE OF GREAT CONSTRICTION OF BOTH MAIN RENAL ARTERIES：THE MALIGNANT PHASE OF EXPERIMENTAL RENAL HYPERTENSION 27
PATHOLOGIC CHANGES IN THE ORGANS OF ANIMALS WITH PERSISTENT HYPERTENSION 29
Pathogenesis of arteriolar necrosis 32
Other changes in experimental renal hypertension 32
PATHOGENESIS(MECHANISM OF DEVELOPMENT) OF EXPERIMENTAL RENAL HYPERTENSION 37
Neurogenic mechanism 39
Endocrinogenic mechanism 40
THE HUMORAL MECHANISM OF EXPERIMENTAL RENAL HYPERTENSION 51
RENAL ORIGIN OF HYPERTENSION 54
RENIN 61
Chemical properties 61
Physiological properties 62
Fate of renin in the body 67
Methods for the assay of renin：the unit of renin 69
HYPERTENSINOGEN 70
Nature and properties 70
Unit of hypertensinogen 71
Preparation 72
Hypertensin 73
Chemical properties 73
Preparation and purification 75
Physiological properties 76
Unit of hypertensin 79
HYPERTENSINASE 80
Nature and properties 80
The unit of hypertensinase 81
The amount of hypertensinase in the blood and various organs 81
Mechanism of action of hypertensinase 82
MECHANISM AND SITE OF FORMATION AND RELEASE OF RENIN 84
THE JUXTAGLOMERULAR APPARATUS 88
THE TREATMENT OF HYPERTENSION 90
Medical Treatment 90
Extracts of kidney 92
Antirenin：treatment of hypertension by the parenteral injection of renin 96
Other vasoconstrictor，pressor and antipressor substances，and their effects 101
Surgical Treatment 109
Unilateral nephrectomy for hypertension due to unilateral renal disease 110
SUMMARY OF THE SIMILARITIES AND DIFFERENCES BETWEEN HUMAN ESSENTIAL AND EXPERIMENTAL HUMAN HYPERTENSION 114